Noriline 10mg. 25mg Tablet
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of endogenous depression and nocturnal enuresis in children over 6 years.
Dosage (summary)
Depression: Initial 25 mg TID, max 150 mg daily. Nocturnal enuresis: 10-50 mg at bedtime for children.
Onset of Action / Duration
Onset: 3-4 days, Duration: up to 30 days for full effect.
Special Populations
- Elderly
- Children
- Cardiovascular disease
- Liver impairment
- Epilepsy
Pregnancy & Breastfeeding
Safety in pregnancy and lactation not established.
Key Drug Interactions
- Monoamine oxidase inhibitors
- CNS depressants
- Barbiturates
- Thyroid preparations
Contraindications
- Sensitivity to amitriptyline
- Post-myocardial infarction
- Heart block
- Children under 6
- MAOIs
Common side effects
- Dry mouth
- Constipation
- Drowsiness
- Tachycardia
- Blurred vision
Counselling Points
- Avoid driving if drowsy
- Monitor for suicidal tendencies
- Gradual dosage reduction recommended
Serious warnings
- Impaired decision making
- Risk of psychosis in schizophrenia
- Manic phase in manic-depressive patients
Important Disclaimer
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