Aprate 5mg or 10mg Tablet
PDF Leaflet Revision Date: 30 December 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of angina pectoris and mild-to-moderate hypertension.
Dosage (summary)
Adults: Initial 5 mg once daily, may increase to 10 mg after 10-14 days.
Onset of Action / Duration
Onset: 6-12 hours, Duration: 24 hours
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not established; contraindicated in pregnancy and lactation.
Key Drug Interactions
- Grapefruit juice
- CYP3A4 inhibitors
- Beta-blockers
Contraindications
- Hypersensitivity to amlodipine
- Severe hypotension
- Shock
- Unstable angina
- Severe aortic stenosis
Common side effects
- Dizziness
- Headache
- Palpitations
- Ankle swelling
- Fatigue
Counselling Points
- Avoid grapefruit juice.
- Monitor for dizziness.
- Do not double doses if missed.
Serious warnings
- Risk of heart failure in severe aortic stenosis
- Gradual withdrawal recommended
Important Disclaimer
The Aprate 5mg or 10mg Tablet professional information leaflet below is the property of Aurogen South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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