Vexfan 6mg Solution for infusion
PDF Leaflet Revision Date: 06 April 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Conditioning treatment prior to haematopoietic progenitor cell transplantation.
Dosage (summary)
0.8 mg/kg body weight as a 2-hour infusion every 6 hours for 4 days.
Special Populations
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy; breastfeeding should be discontinued during treatment.
Key Drug Interactions
- Itraconazole
- Metronidazole
- Paracetamol
Contraindications
- Hypersensitivity to busulfan
- Pregnancy
- Lactation
- Hepatic insufficiency
Common side effects
- Neutropenia
- Thrombocytopenia
- Anaemia
- Seizures
- Confusion
- Dizziness
Counselling Points
- Premedicate with anticonvulsants
- Monitor for infections
- Avoid pregnancy during and 6 months after treatment
Serious warnings
- Profound myelosuppression
- Risk of second malignancy
- Pulmonary toxicity
Important Disclaimer
The Vexfan 6mg Solution for infusion professional information leaflet below is the property of Eurolab and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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