Sinemet 25mg. 100mg, 25mg. 250mg Tablet
PDF Leaflet Revision Date: 18 June 2015
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of Parkinson's disease and syndrome.
Dosage (summary)
Initial: 1 tablet of SINEMET 25/100 three times daily; max: 8 tablets/day.
Onset of Action / Duration
Onset: 1 day, Duration: up to 8 hours.
Special Populations
- Renal impairment
- Hepatic impairment
- Cardiovascular disease
Pregnancy & Breastfeeding
Use in pregnancy only if benefits outweigh risks; levodopa excreted in breast milk.
Key Drug Interactions
- Antihypertensives
- MAO inhibitors
- Iron supplements
Contraindications
- Hypersensitivity
- Narrow angle glaucoma
- Malignant melanoma
Common side effects
- Dyskinesias
- Nausea
- Confusion
- Depression
Counselling Points
- Monitor for sudden sleep onset
- Avoid abrupt discontinuation
- Regular skin checks recommended
Serious warnings
- Risk of melanoma
- Monitor for impulse control disorders
- Caution in cardiovascular disease
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