Sonke Efavirenz 200 mg, 600 mg CAPSULE
PDF Leaflet Revision Date: September 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of HIV-1 in combination with other antiretrovirals.
Dosage (summary)
Adults: 600 mg once daily; children: weight-based dosing.
Special Populations
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy; avoid breastfeeding.
Key Drug Interactions
- Voriconazole
- Rifampicin
- St. John's Wort
Contraindications
- Hypersensitivity
- Severe hepatic impairment
- Pregnancy
- Children <3 years or <13 kg
Common side effects
- Dizziness
- Nausea
- Rash
- Fatigue
Counselling Points
- Take at bedtime to reduce CNS effects
- Use barrier contraception
- Monitor for liver function
Serious warnings
- Serious psychiatric symptoms
- Risk of liver injury
- Immune Reconstitution Inflammatory Syndrome
Important Disclaimer
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