Efrin 600 mg FC tablets,
PDF Leaflet Revision Date: 14 April 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of HIV-1 in adults and children u2265 40 kg.
Dosage (summary)
600 mg orally once daily, preferably at bedtime.
Special Populations
- Hepatic impairment
- Renal impairment
- Elderly patients
- Children < 40 kg
Pregnancy & Breastfeeding
Contraindicated in pregnancy; not recommended during breastfeeding.
Key Drug Interactions
- CYP3A4 inducers/inhibitors
- St. John's Wort
- Cisapride
- Midazolam
- Triazolam
Contraindications
- Hypersensitivity to efavirenz
- Weight < 40 kg
- Severe hepatic impairment
- History of liver injury with efavirenz
Common side effects
- Rash
- Dizziness
- Nausea
- Headache
- Fatigue
Counselling Points
- Take at bedtime to reduce CNS effects
- Use barrier contraception
- Monitor for rash and psychiatric symptoms
Serious warnings
- Serious psychiatric reactions
- Seizures
- QTc prolongation
- Risk of HIV transmission
Important Disclaimer
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