Lexamil 5 mg/ 10mg / 20mg Tablets
PDF Leaflet Revision Date: 28 February 2019
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of major depressive episodes and anxiety disorders.
Dosage (summary)
10 mg daily, may increase to 20 mg based on response; lower doses for elderly and hepatic impairment.
Onset of Action / Duration
Onset: 2-4 weeks, Duration: 30 hours half-life
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not recommended; monitor neonates for withdrawal symptoms.
Key Drug Interactions
- MAOIs
- Linezolid
- CYP2C19 inhibitors
- Tramadol
- St. John's Wort
Contraindications
- Hypersensitivity
- Children <18 years
- QT prolongation
- MAOI use
Common side effects
- Nausea
- Insomnia
- Dizziness
- Fatigue
- Sexual dysfunction
Counselling Points
- Monitor for worsening symptoms
- Avoid abrupt discontinuation
- Caution with driving
Serious warnings
- Suicidal ideation
- Serotonin syndrome
- QT interval prolongation
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