Inechol 10/10 mg, 10/20 mg, 10/40 mg Tablets
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Inechol 10/10 mg, 10/20 mg, 10/40 mg Tablets

S4
PDF Leaflet Revision Date: 09 November 2023
API: Ezetimibe, Simvastatin | Company: Viatris South Africa

Clinical Summary

Quick overview from the medicine insert

Indication

Adjunctive therapy for primary hypercholesterolaemia and HoFH.

Dosage (summary)

Starting dose: 10/20 mg/day; max: 10/80 mg/day.

Special Populations

  • Elderly
  • Hepatic impairment
  • Renal impairment

Pregnancy & Breastfeeding

Contraindicated in pregnancy and lactation.

Key Drug Interactions

  • CYP3A4 inhibitors
  • Fibrates
  • Ciclosporin
  • Danazol

Contraindications

  • Hypersensitivity
  • Active liver disease
  • Moderate to severe hepatic impairment
  • Pregnancy
  • Lactation
  • Children

Common side effects

  • Headache
  • Abdominal pain
  • Diarrhoea
  • Myopathy
  • Rhabdomyolysis

Counselling Points

  • Take in the evening
  • Avoid grapefruit juice
  • Report muscle pain or weakness

Serious warnings

  • Risk of myopathy/rhabdomyolysis
  • Monitor liver enzymes
  • Caution in alcohol use

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Inechol 10/10 mg, 10/20 mg, 10/40 mg Tablets
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