Aspen Trazodone 50 mg or 100 mg Capsule

Indication

Management of major depressive disorder and anxiety disorders.

Dosage (summary)

Initial dose of 150 mg/day, which may be increased to a maximum of 400 mg/day based on clinical response.

Onset of Action / Duration

Effects may be observed within 1 to 2 weeks, with full therapeutic effects typically seen after 4 to 6 weeks.

Special Populations

• Elderly patients
• Patients with hepatic impairment
• Patients with renal impairment

Pregnancy & Breastfeeding

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Trazodone is excreted in breast milk; caution is advised when administered to nursing mothers.

Key Drug Interactions

• CNS depressants (e.g., alcohol, benzodiazepines) may enhance sedative effects.
• Monoamine oxidase inhibitors (MAOIs) can lead to serious interactions.
• Serotonergic drugs may increase the risk of serotonin syndrome.

Contraindications

• Hypersensitivity to trazodone or any of its components.
• Recent myocardial infarction.
• Concurrent use with MAOIs.

Common side effects

• Drowsiness
• Dizziness
• Dry mouth
• Nausea
• Constipation
• Blurred vision

Counselling Points

• Take trazodone at the same time each day to maintain an even level in your system.
• Avoid alcohol while taking this medication.
• Do not discontinue abruptly; consult your healthcare provider for a tapering schedule.
• Report any signs of serotonin syndrome, such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering, blurred vision, muscle spasm or stiffness.