Vicomyl 200 Mg IV Powder for solution for infusion.

Indication

Treatment of invasive aspergillosis and serious Candida infections.

Dosage (summary)

Loading: 6 mg/kg every 12 hours for 24 hours; Maintenance: 3-4 mg/kg every 12 hours.

Special Populations

• Elderly: No dose adjustment needed.
• Renal impairment: Monitor creatinine; consider oral therapy if severe.
• Hepatic impairment: Halve maintenance dose in mild to moderate cirrhosis.

Pregnancy & Breastfeeding

Contraindicated in pregnancy; breastfeeding not recommended during treatment.

Key Drug Interactions

• CYP3A4 substrates (e.g., ergot alkaloids, sirolimus) - contraindicated.
• Rifampicin, carbamazepine - contraindicated.
• Phenytoin - monitor levels if co-administered.

Contraindications

• Hypersensitivity to voriconazole.
• Severe hepatic impairment (Child-Pugh Class C).
• Co-administration with certain CYP3A4 substrates.

Common side effects

• Visual impairment.
• Liver function test abnormalities.
• Nausea, vomiting, diarrhea.

Counselling Points

• Avoid sun exposure; use sunscreen.
• Report any skin lesions or visual changes.
• Use effective contraception during treatment.