Adco-Zidovudine Syrup
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of HIV infection in combination with other antiretroviral agents.
Dosage (summary)
The usual adult dose is 300 mg/day, administered as 150 mg twice daily or 200 mg three times daily. For children, the dosage is based on body weight.
Onset of Action / Duration
Onset of action is typically within 1-2 weeks, with maximum effect observed after several weeks of therapy.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly patients
Pregnancy & Breastfeeding
Zidovudine is classified as Category C. It is recommended for use during pregnancy to reduce the risk of HIV transmission from mother to child. Caution is advised during lactation as it is excreted in breast milk.
Key Drug Interactions
- Bone marrow suppressants may increase the risk of hematologic toxicity.
- Ribavirin may increase the risk of anemia when used concurrently.
- Other antiretroviral agents may have additive effects.
Contraindications
- Hypersensitivity to zidovudine or any component of the formulation.
- Severe hepatic impairment.
Common side effects
- Anemia
- Neutropenia
- Nausea
- Headache
- Fatigue
- Myopathy
Counselling Points
- Advise patients to take the medication exactly as prescribed.
- Inform patients about the importance of adherence to therapy.
- Discuss potential side effects and the need for regular blood tests to monitor blood counts.
- Encourage patients to report any signs of infection or unusual bleeding.
Serious warnings
- Monitor for signs of hematologic toxicity, especially in patients with pre-existing conditions.
- Use with caution in patients with a history of liver disease.
- Patients should be advised to avoid alcohol as it may exacerbate side effects.
Important Disclaimer
The Adco-Zidovudine Syrup professional information leaflet below is the property of Adcock Ingram and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
Healthcare Professionals Only
This content is for registered healthcare professionals
Sign in or create a free account to read the full package insert.
Free for HPCSA-registered professionals. Powered by Medinsert.
