Aldactone Tablets
Clinical Summary
Quick overview from the medicine insert
Indication
Management of edema associated with congestive heart failure, liver cirrhosis, and nephrotic syndrome; treatment of hypertension; treatment of primary hyperaldosteronism.
Dosage (summary)
Initial dose for adults is typically 25 mg to 100 mg once daily, adjusted based on clinical response.
Onset of Action / Duration
Diuretic effect usually begins within 24 to 48 hours; maximum effect may take several days.
Special Populations
- Elderly patients
- Patients with renal impairment
- Patients with hepatic impairment
Pregnancy & Breastfeeding
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Spironolactone is excreted in breast milk; caution is advised when administered to nursing mothers.
Key Drug Interactions
- Potassium-sparing diuretics may increase the risk of hyperkalemia when used with other potassium-sparing agents.
- NSAIDs may reduce the diuretic effect of spironolactone.
- ACE inhibitors and ARBs may increase the risk of hyperkalemia.
Contraindications
- Anuria
- Acute renal insufficiency
- Hyperkalemia
- Addison's disease
Common side effects
- Hyperkalemia
- Hypotension
- Dizziness
- Gastrointestinal disturbances
- Gynecomastia
Counselling Points
- Monitor potassium levels regularly during treatment.
- Report any signs of hyperkalemia such as muscle weakness or irregular heartbeat.
- Take the medication as prescribed and do not discontinue without consulting a healthcare provider.
- Avoid potassium supplements and high-potassium foods unless directed by a healthcare provider.
Serious warnings
- Use with caution in patients with renal impairment.
- Monitor blood pressure regularly, especially when initiating therapy.
- Risk of dehydration and electrolyte imbalance; monitor electrolytes periodically.
Important Disclaimer
The Aldactone Tablets professional information leaflet below is the property of Pfizer Laboratories and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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