Aspen Oxaliplatin Injection

Indication

Oxaliplatin is indicated for the treatment of advanced colorectal cancer, in combination with other chemotherapeutic agents.

Dosage (summary)

The recommended dose of oxaliplatin is 85 mg/m² administered as an intravenous infusion over 2 hours every 2 weeks, in combination with infusional 5-fluorouracil and leucovorin.

Onset of Action / Duration

The onset of action is typically within 1-2 weeks, with maximum effect observed after several cycles of treatment.

Special Populations

• Elderly patients may require dose adjustment.
• Patients with hepatic impairment may require dose adjustment.
• Patients with renal impairment may require dose adjustment.

Pregnancy & Breastfeeding

Oxaliplatin is contraindicated in pregnancy and breastfeeding due to potential harm to the fetus or infant.

Key Drug Interactions

• Caution is advised when used with other myelosuppressive agents.
• May interact with anticoagulants, increasing the risk of bleeding.

Contraindications

• Hypersensitivity to oxaliplatin or any of its components.
• Severe bone marrow suppression.
• Pregnancy and lactation.

Common side effects

• Nausea and vomiting.
• Peripheral neuropathy.
• Myelosuppression (neutropenia, thrombocytopenia).
• Diarrhea.
• Fatigue.

Counselling Points

• Advise patients to report any signs of allergic reactions, such as rash or difficulty breathing.
• Instruct patients to maintain hydration and report severe gastrointestinal symptoms.
• Inform patients about the risk of peripheral neuropathy and to report any unusual sensations.