Campto Infusion
PDF Leaflet Revision Date: 09 June 2016
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of advanced colorectal cancer.
Dosage (summary)
350 mg/mu00b2 IV every 3 weeks; 80 mg/mu00b2 weekly or 180 mg/mu00b2 every 2 weeks in combination with 5-FU/FA.
Onset of Action / Duration
Onset: 5 days for delayed diarrhea.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation; may cause fetal harm.
Key Drug Interactions
- Azole antifungals
- St. John's Wort
- Antineoplastic agents
- Neuromuscular blocking agents
Contraindications
- Severe hypersensitivity
- Bilirubin > 1.5 x ULN
- Severe bone marrow failure
- Chronic inflammatory bowel disease
Common side effects
- Diarrhea
- Nausea
- Vomiting
- Neutropenia
- Anemia
Counselling Points
- Hydration and antidiarrheal therapy are crucial
- Avoid pregnancy during treatment
- Report any diarrhea immediately
Serious warnings
- Risk of severe diarrhea
- Monitor for febrile neutropenia
- Use in specialized units only
Important Disclaimer
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