Cloxacillin Fresenius 250 mg, 500 mg Powder for solution for injection

Cloxacillin Fresenius 250 mg, 500 mg Powder for solution for injection

S4
PDF Leaflet Revision Date: 16 September 2024


Clinical Summary

Quick overview from the medicine insert

Indication

Infections caused by penicillinase-producing staphylococci.

Dosage (summary)

250 mg IM every 4-6 hours; 500 mg IV every 4-6 hours.

Special Populations

  • Jaundiced neonates
  • Renal impairment

Pregnancy & Breastfeeding

Safety in pregnancy not established; passes into breast milk.

Key Drug Interactions

  • Aminoglycosides
  • Chloramphenicol
  • Tetracyclines
  • Oral contraceptives
  • Probenecid

Contraindications

  • Hypersensitivity to cloxacillin
  • History of penicillin allergy
  • Neonates from penicillin-sensitive mothers

Common side effects

  • Allergic reactions
  • Nausea
  • Vomiting
  • Diarrhoea
  • Convulsions

Counselling Points

  • Report any allergic reactions
  • Take on an empty stomach for better absorption
  • Monitor for signs of superinfection

Serious warnings

  • Risk of neurotoxicity in renal impairment
  • Potential for severe allergic reactions
Important Disclaimer

The Cloxacillin Fresenius 250 mg, 500 mg Powder for solution for injection professional information leaflet below is the property of Fresenius Kabi South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>

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