Comtan 200mg Tablet
PDF Leaflet Revision Date: 23 July 2010
Clinical Summary
Quick overview from the medicine insert
Indication
Adjunct to levodopa for Parkinson's disease with motor fluctuations.
Dosage (summary)
200 mg with each levodopa dose, max 2 g/day.
Onset of Action / Duration
Onset: 1 hour, Duration: 30 mins.
Special Populations
- Elderly
- Liver impairment
- Renal insufficiency
Pregnancy & Breastfeeding
Safety not established; avoid breastfeeding.
Key Drug Interactions
- MAO inhibitors
- Warfarin
- Catechol-containing drugs
Contraindications
- Hypersensitivity
- Liver impairment
- Pheochromocytoma
- History of NMS
Common side effects
- Dyskinesia
- Nausea
- Diarrhoea
- Abdominal pain
- Dry mouth
Counselling Points
- Monitor for weight loss
- Caution with driving
- Adjust levodopa dosage as needed
Serious warnings
- Risk of NMS
- Rhabdomyolysis
- Somnolence and sudden sleep onset
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