Lioresal 10 mg/ 25 mg Tablet.
PDF Leaflet Revision Date: 27 November 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Spasticity due to multiple sclerosis and spinal cord diseases.
Dosage (summary)
Adults: Start at 5 mg TID, titrate to 30-80 mg daily. Children: Start at 0.3 mg/kg/day.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly patients
Pregnancy & Breastfeeding
Not recommended in pregnancy; minimal transfer to breast milk.
Key Drug Interactions
- CNS depressants
- Tricyclic antidepressants
- Levodopa
Contraindications
- Hypersensitivity to baclofen
- Porphyria
Common side effects
- Sedation
- Somnolence
- Nausea
- Dizziness
Counselling Points
- Take with food
- Avoid alcohol
- Monitor for mood changes
Serious warnings
- Risk of respiratory depression
- Suicidal thoughts
- Abrupt withdrawal may cause seizures
Important Disclaimer
The Lioresal 10 mg/ 25 mg Tablet. professional information leaflet below is the property of Novartis South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
Healthcare Professionals Only
This content is for registered healthcare professionals
Sign in or create a free account to read the full package insert.
Free for HPCSA-registered professionals. Powered by Medinsert.
