Dapicub 500 mg Powder for solution for infusion
Clinical Summary
Quick overview from the medicine insert
Indication
Complicated skin and skin structure infections and Staphylococcus aureus bloodstream infections.
Dosage (summary)
cSSTI: 4 mg/kg once daily for 7-14 days; SAB: 6 mg/kg once daily for 2-6 weeks.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly
Pregnancy & Breastfeeding
Safety in pregnancy and breastfeeding not established.
Key Drug Interactions
- Myopathy with HMG-CoA reductase inhibitors
- False PT/INR prolongation
- Caution with tobramycin
Contraindications
- Hypersensitivity to daptomycin
Common side effects
- Fungal infections
- Anemia
- Dizziness
- Nausea
- Rash
Counselling Points
- Monitor for muscle pain and CPK levels
- Avoid driving if dizziness occurs
- Report any signs of allergic reactions
Serious warnings
- Risk of Clostridium difficile-associated diarrhea
- Eosinophilic pneumonia
- Renal impairment
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