Easan 150 mg Powder for solution for infusion
Clinical Summary
Quick overview from the medicine insert
Indication
Prevention of nausea and vomiting associated with cancer chemotherapy.
Dosage (summary)
150 mg IV on Day 1, no adjustment for elderly or renal impairment.
Onset of Action / Duration
Onset: 30 mins, Duration: Not specified.
Special Populations
- Moderate hepatic impairment
- Severe hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Not recommended in pregnancy; breastfeeding not advised.
Key Drug Interactions
- CYP3A4 inhibitors
- CYP3A4 inducers
- Warfarin
Contraindications
- Hypersensitivity to aprepitant
- Co-administration with pimozide
- Pregnancy
- Breastfeeding
- Paediatric patients
Common side effects
- Fatigue
- Headache
- Constipation
- Dyspepsia
- Hiccups
Counselling Points
- Monitor for hypersensitivity
- Use non-hormonal contraception
- Avoid in pregnancy and breastfeeding
Serious warnings
- Hypersensitivity reactions
- Infusion site reactions
- Caution in hepatic impairment
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