Dexsedate 100 Μg/Ml 100 μg Concentrate for solution for infusion
PDF Leaflet Revision Date: 30 September 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Sedation in ICU and monitored anaesthesia care.
Dosage (summary)
Loading: 1.0 mcg/kg over 10 mins; Maintenance: 0.2-0.7 mcg/kg/h.
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Safety not established; crosses placenta; present in breast milk.
Key Drug Interactions
- Enhanced effects with sedatives and opioids
- Caution with beta blockers
Contraindications
- Hypersensitivity
- Sepsis
- Unstable trauma
- Hypovolaemia
- Heart block
- Uncontrolled cardiac failure
- Imminent hepatic failure
- Uncontrolled hypotension
- Acute cerebrovascular conditions
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Dry mouth
- Hypoxia
Counselling Points
- Avoid driving for 24 hours post-surgery
- Monitor for irritability in breastfed infants
- Fluid supplementation necessary during infusion
Serious warnings
- Continuous monitoring required
- Risk of bradycardia and hypotension
- Not for use in non-surgical ICU patients
Important Disclaimer
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