Irinotecan 40 Mg/ 2 Ml; 100 Mg/5 Ml; 300 Mg/15Ml; 500 Mg/25 Ml Fksa 40 mg/ 2 ml; 100 mg/5 ml; 300 mg/15ml; 500 mg/25 ml Concentrate for solution for infusion
PDF Leaflet Revision Date: 06 November 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of advanced colorectal cancer.
Dosage (summary)
350 mg/mu00b2 IV every 3 weeks for monotherapy; 80 mg/mu00b2 weekly or 180 mg/mu00b2 every 2 weeks for combination therapy.
Onset of Action / Duration
Onset: 5 days for delayed diarrhea, Duration: variable
Special Populations
- Hepatic impairment
- Renal impairment
- Elderly
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding.
Key Drug Interactions
- St John's Wort
- Ketoconazole
- Live attenuated vaccines
Contraindications
- Severe hypersensitivity to irinotecan
- Chronic inflammatory bowel disease
- Severe bone marrow failure
- WHO performance status > 2
- Bilirubin > 1.5 times ULN
Common side effects
- Delayed diarrhea
- Neutropenia
- Nausea
- Vomiting
- Fatigue
Counselling Points
- Stay hydrated and report diarrhea immediately.
- Use effective contraception during treatment.
- Avoid live vaccines.
Serious warnings
- Risk of severe neutropenia
- Risk of life-threatening diarrhea
- Monitor for interstitial lung disease
Important Disclaimer
The Irinotecan 40 Mg/ 2 Ml; 100 Mg/5 Ml; 300 Mg/15Ml; 500 Mg/25 Ml Fksa 40 mg/ 2 ml; 100 mg/5 ml; 300 mg/15ml; 500 mg/25 ml Concentrate for solution for infusion professional information leaflet below is the property of Fresenius Kabi South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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