Macrodantin 50mg. 100mg Capsule
PDF Leaflet Revision Date: 26 September 1996
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment and prevention of uncomplicated lower urinary tract infections.
Dosage (summary)
Adults: 50-100 mg four times daily; prevention: 50-100 mg daily.
Special Populations
- Elderly
- Renal impairment
Pregnancy & Breastfeeding
Contraindicated in late pregnancy and infants under one month; safety in early pregnancy not established.
Key Drug Interactions
- Probenecid
- Sulphinpyrazone
- Magnesium trisilicate
- Quinolones
Contraindications
- Anuria
- Oliguria
- Renal impairment
- Pregnant women at term
- Infants under one month
- Sensitivity to nitrofurantoin
- G6PD deficiency
Common side effects
- Anorexia
- Nausea
- Vomiting
- Skin rashes
- Pulmonary reactions
Counselling Points
- Take with food to minimize gastric upset
- Report signs of peripheral neuropathy
- Urine may turn brown
Serious warnings
- Limit therapy to 14 days
- Monitor pulmonary function in elderly
- Risk of haemolytic anaemia
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