Metrazole 400 mg Tablets
PDF Leaflet Revision Date: 08 August 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of infections caused by anaerobic bacteria and protozoa.
Dosage (summary)
Adults: 400 mg three times daily; adjust for special populations.
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Not recommended during pregnancy; contraindicated in breastfeeding.
Key Drug Interactions
- Alcohol
- Warfarin
- Busulfan
- Cimetidine
- Lithium
Contraindications
- Hypersensitivity
- Blood dyscrasias
- Active CNS disease
- Pregnancy
Common side effects
- Nausea
- Diarrhea
- Dizziness
- Metallic taste
Counselling Points
- Avoid alcohol during and 3 days after treatment
- Monitor for signs of liver injury
- Report any neurological symptoms immediately
Serious warnings
- Disulfiram-like reaction with alcohol
- Pseudomembranous colitis
- Peripheral neuropathy
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