Orizit Paed 75 mg and 50 mg. Dispersible tablet
PDF Leaflet Revision Date: 26 July 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Indicated for pulmonary tuberculosis in children.
Dosage (summary)
Daily: Rifampicin 15 mg/kg (max 600 mg), Isoniazid 10 mg/kg (max 300 mg).
Special Populations
- Hepatic impairment
- Renal impairment
- Diabetes mellitus
- Chronic alcoholism
Pregnancy & Breastfeeding
Safety not established; both drugs cross placenta and are excreted in breast milk.
Key Drug Interactions
- Nevirapine
- Saquinavir/ritonavir
- Alcohol
- Corticosteroids
Contraindications
- Hypersensitivity to rifamycins or isoniazid
- Jaundice
- Hepatic impairment
- Renal impairment
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Hepatitis
- Peripheral neuropathy
Counselling Points
- Take on an empty stomach
- Avoid alcohol
- Monitor for signs of liver damage
Serious warnings
- Serious hepatotoxicity
- Risk of anaphylaxis
- Monitor liver function
Important Disclaimer
The Orizit Paed 75 mg and 50 mg. Dispersible tablet professional information leaflet below is the property of Macleods Pharmaceuticals Sa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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