Duopic Paed 75 & 50 mg Tablets
PDF Leaflet Revision Date: 18 November 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Pulmonary tuberculosis in children.
Dosage (summary)
Daily: Rifampicin 15 mg/kg (max 600 mg), Isoniazid 10 mg/kg (max 300 mg).
Special Populations
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Safety not established; crosses placenta and excreted in breastmilk.
Key Drug Interactions
- Nevirapine
- Saquinavir/Ritonavir
- Corticosteroids
- Warfarin
Contraindications
- Hypersensitivity to rifampicin or isoniazid
- Jaundice
- Severe renal/hepatic impairment
Common side effects
- Hepatotoxicity
- Peripheral neuropathy
- Gastrointestinal disturbances
Counselling Points
- Take on an empty stomach
- Avoid alcohol
- Monitor for jaundice or unusual bleeding
Serious warnings
- Serious hepatotoxicity
- Hypersensitivity reactions
- Monitor liver function
Important Disclaimer
The Duopic Paed 75 & 50 mg Tablets professional information leaflet below is the property of Adcock Ingram and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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