Pendine 5 mg, 10 mg Tablets.
PDF Leaflet Revision Date: 04 August 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of hypertension and angina pectoris.
Dosage (summary)
Initial dose 5 mg once daily, may increase to 10 mg.
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Safety in pregnancy not established; excreted in breast milk.
Key Drug Interactions
- Grapefruit juice
- CYP3A4 inhibitors
- CYP3A4 inducers
- Tacrolimus
- mTOR inhibitors
Contraindications
- Hypersensitivity to amlodipine
- Severe hypotension
- Shock
- Aortic stenosis
- Unstable heart failure
- Grapefruit juice
Common side effects
- Dizziness
- Headache
- Palpitations
- Fatigue
- Ankle swelling
Counselling Points
- Monitor blood pressure regularly
- Avoid grapefruit juice
- Gradual dose reduction recommended upon discontinuation
Serious warnings
- Caution in heart failure
- Risk of hypotension in overdose
Important Disclaimer
The Pendine 5 mg, 10 mg Tablets. professional information leaflet below is the property of Unichem Sa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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