Prandin 1 mg and 2 mg Vaginal Gel
PDF Leaflet Revision Date: 31 January 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Induction of labour in at-term or near-term pregnant patients.
Dosage (summary)
Initial dose: 1 mg into the vaginal canal; may repeat with 1 or 2 mg after 6 hours, max 3 mg.
Special Populations
- Cardiovascular impairment
- Hepatic impairment
- Renal impairment
- Asthma
Pregnancy & Breastfeeding
Use with caution; monitor for uterine activity and fetal heart rate.
Key Drug Interactions
- Concurrent use with oxytocin not recommended
- Exogenous prostaglandin therapy may enhance response
Contraindications
- Hypersensitivity to PGE2
- Grand multiparity
- Previous uterine surgery
- Cephalopelvic disproportion
- Foetal heart rate compromise
- Obstetric conditions favoring surgical intervention
- Unexplained vaginal discharge or bleeding
Common side effects
- Altered fetal heart rate patterns
- Nausea
- Vomiting
- Diarrhoea
- Back pain
- Uterine hypercontractility
- Fever
Counselling Points
- Monitor for signs of hypertonus
- Report any unusual pain or fetal distress
- Follow dosing instructions carefully
Serious warnings
- Continuous monitoring of uterine activity and fetal heart rate recommended
- Risk of uterine rupture with excessive activity
- Caution in patients with ruptured membranes
Important Disclaimer
The Prandin 1 mg and 2 mg Vaginal Gel professional information leaflet below is the property of Pfizer Laboratories and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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