Propofol 2 % (20 Mg/Ml) B. Braun 20 mg/ml) Emulsion for injection or infusion.
Clinical Summary
Quick overview from the medicine insert
Indication
Induction and maintenance of general anaesthesia; sedation in ICU.
Dosage (summary)
Adults: Induction 1.5-2.5 mg/kg; Maintenance 4-12 mg/kg/hr; Elderly: Reduced dose.
Onset of Action / Duration
Onset: 30-40 secs, Duration: varies with infusion rate.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
- Children <3 years
Pregnancy & Breastfeeding
Not recommended in pregnancy; avoid breastfeeding for 24 hours post-administration.
Key Drug Interactions
- CNS depressants
- Opioids
- Benzodiazepines
- Halogenated anaesthetics
Contraindications
- Hypersensitivity to propofol
- Children <3 years
- Severe respiratory depression
Common side effects
- Hypotension
- Apnoea
- Nausea
- Bradycardia
Counselling Points
- Avoid alcohol for 24 hours
- Do not drive or operate machinery post-use
- Monitor for respiratory depression
Serious warnings
- Respiratory depression
- Anaphylaxis risk
- Propofol infusion syndrome
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