Puri-Nethol 50 mg Tablet.
PDF Leaflet Revision Date: 23 December 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of acute leukaemia in adults, adolescents, and children.
Dosage (summary)
2.5 mg/kg bodyweight per day or 50-75 mg/mu00b2 body surface area per day.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly
Pregnancy & Breastfeeding
Avoid during pregnancy; contraindicated in breastfeeding.
Key Drug Interactions
- Allopurinol (reduce dose to 25%)
- Ribavirin (increased toxicity)
- Methotrexate (increased plasma concentrations)
Contraindications
- Hypersensitivity to 6-mercaptopurine or excipients
Common side effects
- Bone marrow suppression
- Leukopenia
- Thrombocytopenia
- Hepatotoxicity
Counselling Points
- Avoid dairy products during administration.
- Monitor for signs of infection.
- Use contraception during and after treatment.
Serious warnings
- Strongly myelosuppressive
- Risk of infections
- Potential for mutagenicity and carcinogenicity
Important Disclaimer
The Puri-Nethol 50 mg Tablet. professional information leaflet below is the property of Pharmacare Ltd and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
Healthcare Professionals Only
This content is for registered healthcare professionals
Sign in or create a free account to read the full package insert.
Free for HPCSA-registered professionals. Powered by Medinsert.
