R-Cin Plus 150 mg and 75 mg Coated tablet.
PDF Leaflet Revision Date: 14 March 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Continuation phase treatment of pulmonary or extra-pulmonary tuberculosis.
Dosage (summary)
Daily for 4 months: Rifampicin 10 mg/kg (max 600 mg), Isoniazid 5 mg/kg (max 300 mg).
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Safety not established; avoid breastfeeding.
Key Drug Interactions
- Saquinavir/ritonavir
- Nevirapine
- Alcohol
Contraindications
- Hypersensitivity to rifamycins
- Jaundice
- Acute porphyria
- Severe renal failure
Common side effects
- Nausea
- Dizziness
- Headache
- Hepatitis
Counselling Points
- Take on an empty stomach
- Avoid alcohol
- Monitor for liver function abnormalities
Serious warnings
- Hepatotoxicity
- Severe hypersensitivity reactions
- Risk of bleeding
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