Solu-Cortef 100 mg and 500 mg Powder for solution for injection.
PDF Leaflet Revision Date: 31 July 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Corticosteroid responsive conditions when oral administration is unsuitable.
Dosage (summary)
Initial IV dose: 100-500 mg; may repeat every 1-10 hours based on response.
Onset of Action / Duration
Onset: 1 hour, Duration: variable.
Special Populations
- Hepatic impairment
- Paediatric population
Pregnancy & Breastfeeding
Use in pregnancy only if necessary; monitor newborn for adrenal insufficiency. Safety in breastfeeding not established.
Key Drug Interactions
- CYP3A4 inhibitors
- CYP3A4 inducers
- NSAIDs
Contraindications
- Hypersensitivity to hydrocortisone
- Systemic fungal infections
- Traumatic brain injury
Common side effects
- Infection
- Hypertension
- Sodium retention
- Diabetes mellitus
Counselling Points
- Monitor for signs of infection
- Avoid abrupt discontinuation
- Report mood changes or severe side effects
Serious warnings
- Adrenal insufficiency risk on abrupt withdrawal
- Increased infection susceptibility
- Psychiatric effects
Important Disclaimer
The Solu-Cortef 100 mg and 500 mg Powder for solution for injection. professional information leaflet below is the property of Pfizer Laboratories and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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