Ukuzid 300 Mg 300 mg Tablet
PDF Leaflet Revision Date: 18 April 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Prophylaxis and treatment of tuberculosis.
Dosage (summary)
Adults: 5-15 mg/kg once daily (max 900 mg).
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
- Slow acetylators
Pregnancy & Breastfeeding
Use in pregnancy not established; avoid during lactation.
Key Drug Interactions
- Increased toxicity with phenytoin, carbamazepine, warfarin
- Reduced absorption with antacids
- Increased hepatotoxicity with rifampicin
Contraindications
- Hypersensitivity to isoniazid
- Alcoholism
- Severe renal failure
- Uncontrolled seizures
Common side effects
- Hepatitis
- Peripheral neuritis
- Optic neuritis
- Gastrointestinal irritation
Counselling Points
- Take on an empty stomach
- Avoid tyramine-rich foods
- Report signs of liver dysfunction
Serious warnings
- Hepatotoxicity risk
- Severe skin reactions (SJS, TEN)
- Monitor for hypersensitivity reactions
Important Disclaimer
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