Zesiton Tablets
PDF Leaflet Revision Date: 02 March 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Monotherapy or add-on treatment for epilepsy and bipolar disorder.
Dosage (summary)
Adults: Initial 25 mg daily, increase to 100-200 mg. Children: 0.6 mg/kg/day, max 400 mg.
Onset of Action / Duration
Onset: 1.4 to 4.8 hours, Duration: 25 hours.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Safety not established in pregnancy and lactation.
Key Drug Interactions
- Valproic acid increases half-life
- Enzyme inducers decrease half-life
Contraindications
- Hypersensitivity to lamotrigine
- Renal and hepatic impairment
- Patients over 65 years
Common side effects
- Skin rash
- Dizziness
- Nausea
- Headache
Counselling Points
- Report any rash or flu-like symptoms immediately.
- Avoid abrupt withdrawal.
- Monitor weight in children.
Serious warnings
- Risk of severe skin reactions
- Monitor for hypersensitivity symptoms
- Risk of withdrawal seizures
Important Disclaimer
The Zesiton Tablets professional information leaflet below is the property of Aurogen South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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