Zytiga 250mg & 500 mg Tablet
PDF Leaflet Revision Date: 15 November 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of high-risk metastatic prostate cancer and metastatic castration-resistant prostate cancer.
Dosage (summary)
1 g daily (two 500 mg or four 250 mg tablets) on an empty stomach.
Special Populations
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy; not for use in women.
Key Drug Interactions
- Strong CYP3A4 inducers
- Corticosteroids
Contraindications
- Hypersensitivity to abiraterone
- Moderate to severe hepatic impairment
- Pregnancy
- Women
Common side effects
- Hypokalaemia
- Hypertension
- Peripheral oedema
- Increased liver enzymes
Counselling Points
- Take on an empty stomach
- Monitor for liver function
- Use contraception during treatment
Serious warnings
- Hepatotoxicity
- Cardiovascular risks
- Mineralocorticoid excess
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