Pendine 5 mg, 10 mg Tablets.
PDF Leaflet Revision Date: 04 August 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of hypertension and angina pectoris.
Dosage (summary)
Initial dose 5 mg once daily, may increase to 10 mg.
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Safety in pregnancy not established; excreted in breast milk.
Key Drug Interactions
- Grapefruit juice
- CYP3A4 inhibitors
- CYP3A4 inducers
- Tacrolimus
- mTOR inhibitors
Contraindications
- Hypersensitivity to amlodipine
- Severe hypotension
- Shock
- Aortic stenosis
- Unstable heart failure
- Grapefruit juice
Common side effects
- Dizziness
- Headache
- Palpitations
- Fatigue
- Ankle swelling
Counselling Points
- Monitor blood pressure regularly
- Avoid grapefruit juice
- Gradual dose reduction recommended upon discontinuation
Serious warnings
- Caution in heart failure
- Risk of hypotension in overdose
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