Lioresal 10 mg/ 25 mg Tablet.
PDF Leaflet Revision Date: 27 November 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Spasticity due to multiple sclerosis and spinal cord diseases.
Dosage (summary)
Adults: Start at 5 mg TID, titrate to 30-80 mg daily. Children: Start at 0.3 mg/kg/day.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly patients
Pregnancy & Breastfeeding
Not recommended in pregnancy; minimal transfer to breast milk.
Key Drug Interactions
- CNS depressants
- Tricyclic antidepressants
- Levodopa
Contraindications
- Hypersensitivity to baclofen
- Porphyria
Common side effects
- Sedation
- Somnolence
- Nausea
- Dizziness
Counselling Points
- Take with food
- Avoid alcohol
- Monitor for mood changes
Serious warnings
- Risk of respiratory depression
- Suicidal thoughts
- Abrupt withdrawal may cause seizures
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