Arbilo Co 50/12,5 or 100/25mg FC tablets

Indication

Management of hypertension and reduction of cardiovascular risk in patients with left ventricular hypertrophy.

Dosage (summary)

The usual starting dose is 50 mg of Losartan and 12.5 mg of Hydrochlorothiazide once daily. The dose may be adjusted based on blood pressure response.

Onset of Action / Duration

Antihypertensive effect may be observed within 3 to 6 hours after administration, with peak effects occurring within 6 to 8 hours.

Special Populations

• Elderly patients may require dose adjustment.
• Patients with renal impairment should be monitored closely.
• Patients with hepatic impairment may require dose adjustment.

Pregnancy & Breastfeeding

Use is not recommended during pregnancy, particularly in the second and third trimesters. Caution is advised during lactation.

Key Drug Interactions

• Potassium-sparing diuretics may increase the risk of hyperkalemia.
• Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the antihypertensive effect.
• Other antihypertensive agents may have additive effects.

Contraindications

• Hypersensitivity to Losartan, Hydrochlorothiazide, or any component of the formulation.
• Severe renal impairment.
• Pregnancy and lactation.

Common side effects

• Dizziness
• Hypotension
• Hyperkalemia
• Fatigue
• Headache

Counselling Points

• Take the medication at the same time each day.
• Monitor blood pressure regularly.
• Report any signs of allergic reaction or severe side effects to a healthcare provider.
• Maintain adequate hydration and avoid excessive potassium intake.