Afaris Paed 75/50 Dispersible tablet

Indication

Treatment of tuberculosis (TB) in pediatric patients.

Dosage (summary)

The recommended dosage for children is based on body weight: 10 mg/kg of Rifampicin and 5 mg/kg of Isoniazid, administered once daily.

Onset of Action / Duration

Therapeutic effects may be observed within 2 to 4 weeks of initiation of therapy.

Special Populations

• Hepatically impaired patients
• Renally impaired patients
• Children under 2 years of age

Pregnancy & Breastfeeding

Rifampicin and Isoniazid are generally considered safe during pregnancy; however, they should only be used if the benefits outweigh the risks. Caution is advised during lactation as both drugs are excreted in breast milk.

Key Drug Interactions

• May reduce the effectiveness of oral contraceptives.
• Concurrent use with anticoagulants may increase the risk of bleeding.
• May interact with antiretroviral medications.

Contraindications

• Hypersensitivity to Rifampicin or Isoniazid.
• Active liver disease or severe hepatic impairment.
• History of drug-induced hepatitis.

Common side effects

• Hepatotoxicity
• Gastrointestinal disturbances (nausea, vomiting)
• Rash
• Peripheral neuropathy
• Orange discoloration of bodily fluids

Counselling Points

• Advise patients to take the medication on an empty stomach.
• Inform patients about the potential side effects and the importance of adherence to therapy.
• Encourage patients to report any signs of liver dysfunction, such as jaundice or dark urine.