Akurit Kid 75/50 Oral Dispersible Tablets
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of tuberculosis (TB) in combination with other antitubercular agents.
Dosage (summary)
The usual adult dosage is 10 mg/kg of Rifampicin and 5 mg/kg of Isoniazid, administered once daily. Dosage may vary based on clinical response and specific patient factors.
Onset of Action / Duration
Rifampicin: onset within hours; peak effect in 2-4 hours. Isoniazid: onset within 1-2 hours; peak effect in 1-2 hours.
Special Populations
- Hepatically impaired patients
- Renally impaired patients
- Elderly patients
- Pediatric patients
Pregnancy & Breastfeeding
Use with caution during pregnancy; benefits must outweigh risks. Isoniazid is excreted in breast milk; monitor infant for side effects.
Key Drug Interactions
- May reduce the effectiveness of oral contraceptives.
- Increased risk of hepatotoxicity with alcohol.
- May interact with anticoagulants, anticonvulsants, and other medications metabolized by the liver.
Contraindications
- Hypersensitivity to Rifampicin or Isoniazid.
- Active liver disease or severe hepatic impairment.
- History of acute liver injury related to isoniazid.
Common side effects
- Hepatotoxicity
- Gastrointestinal disturbances (nausea, vomiting)
- Peripheral neuropathy
- Rash
- Flu-like symptoms
Counselling Points
- Take medication exactly as prescribed.
- Report any signs of liver dysfunction (jaundice, dark urine, persistent nausea).
- Avoid alcohol during treatment.
- Inform healthcare provider of all medications being taken.
Serious warnings
- Monitor liver function tests regularly.
- Risk of drug interactions; review all concurrent medications.
- May cause discoloration of bodily fluids (urine, sweat, tears).
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