Afilat Tablets
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of erectile dysfunction and pulmonary arterial hypertension.
Dosage (summary)
5 mg to 20 mg taken orally as needed, approximately 30 minutes before sexual activity; for pulmonary arterial hypertension, 40 mg once daily.
Onset of Action / Duration
Effects may be observed within 30 minutes, with a duration of action up to 36 hours.
Special Populations
- Elderly patients
- Patients with renal impairment
- Patients with hepatic impairment
Pregnancy & Breastfeeding
Not recommended during pregnancy and lactation; safety has not been established.
Key Drug Interactions
- Nitrates (e.g., nitroglycerin) - increased risk of hypotension
- Alpha-blockers - may enhance hypotensive effects
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) - may increase tadalafil levels
Contraindications
- Severe cardiovascular disorders
- Concurrent use of nitrates
- Hypersensitivity to tadalafil or any component of the formulation
Common side effects
- Headache
- Dyspepsia
- Back pain
- Flushing
- Nasal congestion
- Vision changes
Counselling Points
- Take as directed; do not exceed the recommended dose.
- Avoid alcohol as it may increase the risk of side effects.
- Seek immediate medical attention for sudden vision loss or hearing changes.
- Inform healthcare provider of all medications being taken.
Serious warnings
- Use with caution in patients with a history of cardiovascular disease.
- Not for use in women or children.
- May cause priapism; seek medical help if an erection lasts longer than 4 hours.
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