Anafranil 10 mg, 25mg Tablet or SR 75mg Divitabs
PDF Leaflet Revision Date: 24 May 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of depressive episodes, OCD, and cataplexy.
Dosage (summary)
Adults: Start with 25 mg 2-3 times daily; max 250 mg. Elderly: Start with 10 mg daily, increase to 30-50 mg.
Special Populations
- Elderly
- Children and adolescents
Pregnancy & Breastfeeding
Not recommended during pregnancy; may harm fetus. Clomipramine passes into breast milk.
Key Drug Interactions
- MAO-inhibitors
- SSRIs
- CYP2D6 inhibitors
Contraindications
- Hypersensitivity to clomipramine
- Recent myocardial infarction
- Severe liver disease
- Hypokalaemia
Common side effects
- Dry mouth
- Constipation
- Dizziness
- Fatigue
Counselling Points
- Avoid abrupt discontinuation
- Monitor for worsening depression
- Caution with alcohol and CNS depressants
Serious warnings
- Risk of suicide
- QTc prolongation
- Serotonin syndrome
Important Disclaimer
The Anafranil 10 mg, 25mg Tablet or SR 75mg Divitabs professional information leaflet below is the property of Equity Pharmaceuticals and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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