Asotrim 50mg Tablets
PDF Leaflet Revision Date: 02 February 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Immunosuppressant for organ transplants, inflammatory bowel disease, and autoimmune diseases.
Dosage (summary)
Loading: up to 5 mg/kg/day; Maintenance: 1-4 mg/kg/day orally.
Onset of Action / Duration
Onset: weeks to months, Duration: long-term.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy; not recommended during breastfeeding.
Key Drug Interactions
- Allopurinol (reduce ASOTRIM dose to 25%)
- Ribavirin (not advised)
- TPMT-deficiency (requires dose reduction)
Contraindications
- Hypersensitivity to azathioprine
- Pregnancy
- Acute infections
Common side effects
- Leukopenia
- Nausea
- Vomiting
- Infections
Counselling Points
- Take on an empty stomach
- Report signs of infection
- Monitor for bruising or bleeding
Serious warnings
- Risk of malignancies
- Bone marrow suppression
- Hepatotoxicity
Important Disclaimer
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