Azilect 1mg Tablet

Indication

Management of Parkinson's disease as monotherapy or adjunct therapy.

Dosage (summary)

Initial dose of 1 mg once daily. May be increased to 2 mg once daily based on clinical response.

Onset of Action / Duration

Effects may be observed within 1-2 weeks of initiation.

Special Populations

• Elderly patients
• Patients with hepatic impairment
• Patients taking concomitant medications

Pregnancy & Breastfeeding

Rasagiline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if rasagiline is excreted in human milk; caution should be exercised when administering to nursing mothers.

Key Drug Interactions

• Avoid concomitant use with other MAO inhibitors.
• Caution with antidepressants (e.g., SSRIs, SNRIs) due to risk of serotonin syndrome.
• Avoid tyramine-rich foods to prevent hypertensive crisis.

Contraindications

• Hypersensitivity to rasagiline or any component of the formulation.
• Concomitant use with other MAO inhibitors.
• Severe hepatic impairment.

Common side effects

• Headache
• Dizziness
• Nausea
• Insomnia
• Orthostatic hypotension

Counselling Points

• Inform patients about the potential for dizziness and advise caution when driving or operating machinery.
• Advise patients to report any unusual mood changes or suicidal thoughts.
• Instruct patients to avoid foods high in tyramine.