Disprin Extra Strength 300 / 500mg Tablet

Disprin Regular Strength 300mg and Disprin Extra Strength 500mg are indicated for the relief of mild to moderate pain, and fever.

Disprin Regular Strength 300 mg: Adults: 1-3 tablets. Repeat 4 hourly if necessary but not more than 12 tablets during any 24- hour period. Children 16 years and over: 1-2 tablets not more than four times a day, to a maximum of 10 tablets in 24 hours. Disprin Regular Strength 300 mg can be dissolved in water, or if preferred, on the tongue.

Disprin Extra Strength 500 mg: Adult: 1-2 tablets Children over 16 years: 1 tablet Repeat 4 hourly if necessary but not more than 8 tablets during 24 hour period, but if symptoms persist consult your doctor. In chronic Rheumatic disease, 1-2 tablets every 4 hours over long period. In acute rheumatism, 2-4 tablets four times daily. Disprin Extra Strength 500 mg should be dissolved in water before being taken. If symptoms persist consult your doctor. Do not use continuously for more than 10 days without consulting your doctor.

Patients with peptic ulcers, haemophilia or intolerance (hypersensitivity) to aspirin, sever renal impairment and patients receiving oral anticoagulant therapy. Aspirin should not be taken during the first and trimesters of pregnancy and lactation. Not to be used in children under the age of 16 years.

DO NOT USE CONTINUOUSLY FOR MORE THAN 10 DAYS WITHOUT CONSULTING YOUR DOCTOR. There is a possible association between aspirin and Reye's syndrome when given to children. Reyeu2019s syndrome is a very rare disease which affects the brain and liver and can be fatal. For this reason, aspirin should not be given to children under the age of 16 years unless specifically indicated by a doctor or pharmacist.

Dizziness, Irritation of the gastric mucosa and resultant dyspepsia, haematemesis and melaena may occur in some cases. Concomitant therapy with other gastric irritants, such as non-steroidal anti-inflammatory agents may increase the risk of gastric irritation. Disprin Regular Strength 300 mg and Disprin Extra Strength 500 mg should be withdrawn one week before surgery because of the possibility of increasing the bleeding times. Aspirin may cause allergic reactions, more commonly in asthmatics. Some persons, especially asthmatics, exhibit notable sensitivity to aspirin which may provoke various hypersensitivity reactions which may include skin eruptions, paroxysmal bronchospasm and dyspnoea. Aspirin should be administered with caution to patients with impaired renal function, dyspepsia, anaemia and when the patient is dehydrated.

Aspirin may enhance the activity of coumarin anticoagulants, methotrexate and oral anti-diabetic preparations and sulphonamides. Aspirin diminishes the effect of anti-gout preparations such as probenecid and sulphinpyrazone. Barbiturates and other sedatives may mask the respiratory symptoms of aspirin overdosage and have been reported to enhance its toxicity. Prolonged use of high doses may lead to anaemia, blood dyscrasias, gastro-intestinal haemorrhage, peptic ulceration and renal papillary necrosis. Interference with laboratory tests: Salicylates may produce falsely increased results for blood creatinine, urate (low dose aspirin) and urea. Falsely decreased results may be obtained for blood thyroxine and urate (>4g/day aspirin) and for urinary 5-HIAA (with nitrosoonaphthol method). Urinary VMA (HMMA) levels may be falsely increased or decreased depending on the method of analysis. Urinary glucose oxidase: Aspirin may cause a false negative test in the presence of glycosuria.

Aspirin should not be taken during the first and trimesters of pregnancy and lactation.

Not specified in the provided text.

Dizziness, Irritation of the gastric mucosa and resultant dyspepsia, haematemesis and melaena may occur in some cases. Aspirin may cause allergic reactions, more commonly in asthmatics. Some persons, especially asthmatics, exhibit notable sensitivity to aspirin which may provoke various hypersensitivity reactions which may include skin eruptions, paroxysmal bronchospasm and dyspnoea.

These include dizziness, tinnitus, sweating, nausea, vomiting, altered glucose metabolism, mental confusion, hyperventilation, respiratory alkalosis, metabolic acidosis, ketosis, and fluid and electrolyte losses. Depression of the central nervous system may lead to coma Cardiovascular collapse and respiratory failure. In children, serious signs of overdosage may develop rapidly. In cases of overdosage, consult a doctor immediately. Treatment is symptomatic and supportive: the serum salicylate levels should be closely monitored and forced alkaline diuresis instituted if appropriate. Gastric lavage, restoration of fluid, electrolyte and acid balance, dialysis and supportive therapy may be required.