Emend 80mg and 125mg CAPSULES and COMBIPACK
PDF Leaflet Revision Date: 10 June 2016
Clinical Summary
Quick overview from the medicine insert
Indication
Prevention of acute and delayed nausea and vomiting associated with chemotherapy.
Dosage (summary)
125 mg orally 1 hour prior to chemotherapy on Day 1, then 80 mg once daily on Days 2 and 3.
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Safety in pregnancy not established; avoid breastfeeding.
Key Drug Interactions
- CYP3A4 inhibitors
- Warfarin
- Hormonal contraceptives
Contraindications
- Hypersensitivity to components
- Concurrent use with pimozide, astemizole, cisapride
Common side effects
- Hiccups
- Increased ALT
- Dyspepsia
- Constipation
- Headache
Counselling Points
- Take 1 hour before chemotherapy
- Use backup contraception during and 28 days after treatment
- Monitor for side effects
Serious warnings
- Caution with CYP3A4 medications
- Monitor INR in warfarin patients
- Reduced efficacy of hormonal contraceptives
Important Disclaimer
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