Esbriet 267 mg Capsules
PDF Leaflet Revision Date: 21 September 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Reduction of progression of mild to moderately severe idiopathic pulmonary fibrosis (IPF).
Dosage (summary)
Initial: 801 mg/day (3 capsules, TID) for 14 days, then 2403 mg/day (9 capsules, TID).
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Not recommended during pregnancy or breastfeeding.
Key Drug Interactions
- Fluvoxamine
- CYP1A2 inducers
- Ciprofloxacin
Contraindications
- Hypersensitivity to pirfenidone
- Severe hepatic impairment
- Severe renal impairment
- History of angioedema
Common side effects
- Nausea
- Diarrhoea
- Fatigue
- Rash
- Dizziness
Counselling Points
- Take with food to reduce nausea
- Avoid sun exposure
- Monitor liver function regularly
Serious warnings
- Drug-Induced Liver Injury
- Photosensitivity reactions
- Angioedema
Important Disclaimer
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