Fentanyl 500 ΜG/10 Ml Fresenius, Fentanyl 100 ΜG/2 Ml Fresenius 500 µg/10 mL, 100 µg/2 mL Solution for injection
PDF Leaflet Revision Date: 23 October 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Opioid analgesic supplement during anesthesia.
Dosage (summary)
1-10 u03bcg/kg for induction; 0.5-10 u03bcg/kg bolus; 0.5-5 u03bcg/kg continuous infusion.
Onset of Action / Duration
Onset: Immediate, Duration: 30-60 mins
Special Populations
- Elderly
- Renal impairment
- Obese patients
- Children (2-12 years)
Pregnancy & Breastfeeding
Not recommended in pregnancy; may cause respiratory depression in neonates; avoid breastfeeding for 24 hours post-administration.
Key Drug Interactions
- CNS depressants
- MAO inhibitors
- CYP3A4 inhibitors
- Serotonergic medications
Contraindications
- Hypersensitivity to fentanyl or opioids
- Respiratory depression
- Acute alcoholism
- Head injuries
- Bronchial asthma
- Comatose patients
Common side effects
- Respiratory depression
- Bradycardia
- Nausea
- Dizziness
- Muscle rigidity
Counselling Points
- Avoid driving for 24 hours post-administration.
- Monitor for signs of respiratory depression.
- Discuss risks of dependence and withdrawal.
Serious warnings
- Risk of respiratory depression
- Potential for abuse and dependence
- Monitor for serotonin syndrome
Important Disclaimer
The Fentanyl 500 ΜG/10 Ml Fresenius, Fentanyl 100 ΜG/2 Ml Fresenius 500 µg/10 mL, 100 µg/2 mL Solution for injection professional information leaflet below is the property of Fresenius Kabi South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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