Imbruvica_ 140 Mg Capsules 140 mg Capsules
PDF Leaflet Revision Date: 25 March 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of MCL, CLL, and WM in adults.
Dosage (summary)
MCL: 560 mg once daily; CLL/WM: 420 mg once daily.
Special Populations
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy; avoid breastfeeding during treatment.
Key Drug Interactions
- Strong CYP3A inhibitors
- St. John's Wort
Contraindications
- Hypersensitivity to ibrutinib
- Pregnancy
- Severe hepatic impairment
Common side effects
- Diarrhoea
- Neutropenia
- Rash
- Thrombocytopenia
Counselling Points
- Take with water, do not crush capsules
- Avoid grapefruit juice
- Monitor for signs of bleeding
Serious warnings
- Bleeding events
- Hepatic failure
- Cardiac dysrhythmias
Important Disclaimer
The Imbruvica_ 140 Mg Capsules 140 mg Capsules professional information leaflet below is the property of Janssen Pharmaceutica (Pty) Ltd and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
Healthcare Professionals Only
This content is for registered healthcare professionals
Sign in or create a free account to read the full package insert.
Free for HPCSA-registered professionals. Powered by Medinsert.
