Pretamyl 200 mg Tablets
PDF Leaflet Revision Date: 30 May 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of adults with XDR or treatment-intolerant MDR tuberculosis.
Dosage (summary)
200 mg orally once daily for 26 weeks, in combination with bedaquiline and linezolid.
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding.
Key Drug Interactions
- CYP3A4 inducers
- Rifampicin
- Efavirenz
Contraindications
- Hypersensitivity to pretomanid
- Use with contraindicated drugs
- Pregnancy and lactation
Common side effects
- Anaemia
- Peripheral neuropathy
- Visual impairment
- Increased transaminases
Counselling Points
- Take with food.
- Adhere to the full course of therapy.
- Monitor for visual changes.
- Avoid alcohol and hepatotoxic drugs.
Serious warnings
- Hepatotoxicity
- Myelosuppression
- QT prolongation
- Lactic acidosis
Important Disclaimer
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