Rescuvolin 15mg, 50mg Tablets, Powder for Injection
Clinical Summary
Quick overview from the medicine insert
Indication
Antidote to folic acid antagonists like methotrexate.
Dosage (summary)
Administer 75 mg IV within 12 hours of methotrexate, then 12 mg IM every 6 hours for 4 doses.
Special Populations
- Renal impairment
- Gastrointestinal obstruction
Pregnancy & Breastfeeding
Safety in pregnancy and lactation not established.
Key Drug Interactions
- Enhances toxicity of fluorouracil
- May increase seizures with barbiturates
Contraindications
- Hypersensitivity to folinic acid
- Vitamin B12 deficiency
- Stomach and bowel complaints
Common side effects
- Allergic reactions
- Seizures
- Gastrointestinal complaints
Counselling Points
- Take as soon as possible after methotrexate overdose
- Monitor plasma methotrexate levels
Serious warnings
- Not for pernicious anemia treatment
- Neurological damage may occur
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